Article
RBM-MHC: A Semi-Supervised Machine-Learning Method for Sample-Specific Prediction of Antigen Presentation by HLA-I Alleles.
Cell systems - 17 Feb 2021
Bravi Barbara, Tubiana Jérôme, Cocco Simona, Monasson Rémi, Mora Thierry, Walczak Aleksandra M
Abstract excerpt
The recent increase of immunopeptidomics data, obtained by mass spectrometry or binding assays, opens up possibilities for investigating endogenous antigen presentation by the highly polymorphic human leukocyte antigen class I (HLA-I) protein. State-of-the-art methods predict with high accuracy presentation by HLA alleles that are well represented in databases at the time of release but have a poorer performance...
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