Article

Orthanq: transparent and uncertainty-aware haplotype quantification with application in HLA-typing

2024-02-02

Abstract excerpt

<title>Abstract</title> <p>Background Identification of Human leukocyte antigen (HLA) types from DNA-sequenced human samples is important in organ transplantation and cancer immunotherapy and remains a challenging task considering sequence homology and extreme polymorphism of HLA genes. Results We present Orthanq, a novel statistical model and corresponding application for transparent and uncertainty-aware quanti...

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Literature Corpus work: f47c92cb-817e-5400-94f6-408b6d8de650
DOI: 10.21203/rs.3.rs-3910990/v1

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