HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replication.

doi:10.1016/j.jhep.2024.10.047

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Article

HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replication.

Journal of hepatology - 1 May 2025

Schwarz Tatjana, Ptok Johannes, Damagnez Maximilian, Menne Christopher, Alizei Elahe Salimi, Lang-Meli Julia, Maas Michelle, Habermann Daniel, Hoffmann Daniel, Schulze Zur Wiesch Julian, Lauer Georg M, Kefalakes Helenie, Cornberg Markus, Kraft Anke R M, Gliga Smaranda, Bock Hans H, Horn Peter A, Maini Mala K, Thimme Robert, Wedemeyer Heiner, Nattermann Jacob, Heinemann Falko M, Luedde Tom, Neumann-Haefelin Christoph, Walker Andreas, Timm Jörg

Abstract excerpt

BACKGROUND & AIMS: Immune responses by CD8 T cells are essential for control of HBV replication. Although selection of escape mutations in CD8 T-cell epitopes has previously been described in HBV infection, its overall influence on HBV sequence diversity and correlation with markers of HBV replication remain unclear. METHODS: Whole-genome sequencing was applied to HBV isolates from 532 patients with chronic HBV...

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PMID: 39536821
DOI: 10.1016/j.jhep.2024.10.047

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