Article

Insights to HIV-1 coreceptor usage by estimating HLA adaptation with Bayesian generalized linear mixed models

2022-07-06

Abstract excerpt

The mechanisms triggering the human immunodeficiency virus type I (HIV-1) to switch the coreceptor usage from CCR5 to CXCR4 during the course of infection are not entirely understood. While low CD4 + T cell counts are associated with CXCR4 usage, a predominance of CXCR4 usage with still high CD4 + T cell counts remains puzzling. Here, we explore the hypothesis that viral adaptation to the human leukocyte antigen...

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Literature Corpus work: a3d2c091-da2e-560a-abfd-58a7732bccd3
DOI: 10.1101/2022.07.06.498925

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