Article

Combinatorial <i>in silico</i> approach for cancer-associated 4Fe-4S protein discovery

2023-11-13

Abstract excerpt

Iron-sulfur (Fe-S) proteins play vital roles in multiple cellular processes, including mediating redox balance as well as DNA replication and repair. Given the role of Fe-S cofactors in genome maintenance, mutations in such metalloproteins could be associated with cancer. Nevertheless, only a few cancer-associated Fe-S proteins have been identified. In vitro , Fe-S cluster is susceptible to degradation in oxic en...

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Literature Corpus work: 1baff015-dd7c-57ce-9ea7-64b51334b6a3
DOI: 10.1101/2023.11.08.566327

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