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Article

Computational Simulations of DNA Polymerases: Detailed Insights on Structure/Function/Mechanism from Native Proteins to Cancer Variants.

Chemical research in toxicology - 20 Nov 2017

Walker Alice R, Cisneros G Andrés

Abstract excerpt

Genetic information is vital in the cell cycle of DNA-based organisms. DNA polymerases (DNA Pols) are crucial players in transactions dealing with these processes. Therefore, the detailed understanding of the structure, function, and mechanism of these proteins has been the focus of significant effort. Computational simulations have been applied to investigate various facets of DNA polymerase structure and...

Topics

Amino Acid Sequence
Animals
Catalytic Domain
Computer Simulation
DNA-Directed DNA Polymerase
Humans
Metals
Models, Molecular
Mutagenesis
Mutagens
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasms

Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 28877429
DOI: 10.1021/acs.chemrestox.7b00161
PMCID: PMC5696005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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