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Article

Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein.

Nucleic acids research - 15 Oct 2015

Perugino Giuseppe, Miggiano Riccardo, Serpe Mario, Vettone Antonella, Valenti Anna, Lahiri Samarpita, Rossi Franca, Rossi Mosè, Rizzi Menico, Ciaramella Maria

Abstract excerpt

Alkylated DNA-protein alkyltransferases repair alkylated DNA bases, which are among the most common DNA lesions, and are evolutionary conserved, from prokaryotes to higher eukaryotes. The human ortholog, hAGT, is involved in resistance to alkylating chemotherapy drugs. We report here on the alkylated DNA-protein alkyltransferase, SsOGT, from an archaeal species living at high temperature, a condition that...

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Identifiers

PMID: 26227971
DOI: 10.1093/nar/gkv774
PMCID: PMC4605297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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