Article

A biophysical and structural analysis of DNA binding by oligomeric hSSB1 (NABP2/OBFC2B)

2020-08-27

Abstract excerpt

The oxidative modification of DNA can result in the loss of genome integrity and must be repaired to maintain overall genomic stability. We have recently demonstrated that human single stranded DNA binding protein 1 (hSSB1/NABP2/OBFC2B) plays a crucial role in the removal of 8-oxo-7,8-dihydro- guanine (8-oxoG), the most common form of oxidative DNA damage. The ability of hSSB1 to form disulphide-bonded tetramers a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 92f04950-8fd8-585f-97ec-e36b9a367330
DOI: 10.1101/2020.08.26.269084

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A biophysical and structural analysis of DNA binding by oligomeric hSSB1 (NABP2/OBFC2B)DOI 10.1101/2020.08.26.269084Read

A data-driven structural model of hSSB1 (NABP2/OBFC2B) self-oligomerization.Semantic proximity Read

Dynamic Processing of a Common Oxidative DNA Lesion by the First Two Enzymes of the Base Excision Repair Pathway.Semantic proximity Read

hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity.Semantic proximity Read

Aromatic residues in the oligonucleotide binding domain are essential to the function of the single-stranded DNA binding protein of Helicobacter pylori.Semantic proximity Read

The H-NS dimerization domain defines a new fold contributing to DNA recognition.Semantic proximity Read

Revealing A-T and G-C Hoogsteen base pairs in stressed protein-bound duplex DNA.Semantic proximity Read

A structural model for the damage-sensing complex in bacterial nucleotide excision repair.Semantic proximity Read

Structure of the Human MutSα DNA Lesion Recognition ComplexSemantic proximity Read

The Impact of Single-Stranded DNA-Binding Protein SSB and Putative SSB-Interacting Proteins on Genome Integrity in the Thermophilic Crenarchaeon Sulfolobus acidocaldarius.Semantic proximity Read

Understanding of the activity of a protein involved in DNA repair by biochemical, structural and <i>in silico</i> approachesSemantic proximity Read

Characterization of a single-stranded DNA-binding protein from Klebsiella pneumoniae: mutation at either Arg73 or Ser76 causes a less cooperative complex on DNA.Semantic proximity Read

Structural insights into the unique single-stranded DNA-binding mode of Helicobacter pylori DprASemantic proximity Read