Article

Decoding protein dynamicity in DNA ligase activity through deep learning-based structural ensembles

2024-11-07

Abstract excerpt

<h4>ABSTRACT</h4> Numerous proteins perform their functions by transitioning between various structures. Understanding the conformational ensembles associated with these states is essential for uncovering crucial mechanistic aspects that regulate protein function. In this study, we utilized AlphaFold3 ( AF3 ) to investigate the structural dynamics and mechanisms of enzymes involved in DNA homeostasis, using NAD-...

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Literature Corpus work: 12e2812a-81bc-5714-a91b-6e52bb6386ec
DOI: 10.1101/2024.11.07.622521

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