Article

Dynamic changes in chromosome and nuclear architecture during maturation of normal and ALS C9orf72 motor neurons

2025-09-22

Abstract excerpt

We have investigated changes in chromosome conformation, nuclear organization, and transcription during differentiation and maturation of control and mutant motor neurons harboring hexanucleotide expansions in the C9orf72 gene that cause amyotrophic lateral sclerosis (ALS). Using an in vitro reprogramming, differentiation and neural maturation protocol, we obtained highly purified populations of post-mitotic mot...

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Literature Corpus work: 65fe1884-9ffd-5fd5-9d3b-4569cb480875
DOI: 10.1101/2025.09.22.677835

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