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Phenotypic and Functional Alterations in Peripheral Blood Mononuclear Cell-Derived Microglia in a Primate Model of Chronic Alcohol Consumption

2025-02-06

Abstract excerpt

<h4>ABSTRACT</h4> Alcohol-induced dysregulation of microglial activity is associated with neuroinflammation, cognitive decline, heightened risk for neurodegenerative diseases, alcohol dependence, and escalation of alcohol drinking. Given the challenge of longitudinally sampling primary microglia, we optimized an in vitro method to differentiate peripheral blood mononuclear cells (PBMC) from non-human primates (N...

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Literature Corpus work
65ef5a07-69cf-56bb-90b9-b92ca15345db
DOI
10.1101/2025.02.05.636708
Open publication

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Phenotypic and Functional Alterations in Peripheral Blood Mononuclear Cell-Derived Microglia in a Primate Model of Chronic Alcohol ConsumptionDOI 10.1101/2025.02.05.636708
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