Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model.

doi:10.1126/sciadv.ado5820

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model.

Science advances - 8 Nov 2024

Li Xindi, Liu Jiayi, Boreland Andrew J, Kapadia Sneha, Zhang Siwei, Stillitano Alessandro C, Abbo Yara, Clark Lorraine, Lai Dongbing, Liu Yunlong, Barr Peter B, Meyers Jacquelyn L, Kamarajan Chella, Kuang Weipeng, Agrawal Arpana, Slesinger Paul A, Dick Danielle, Salvatore Jessica, Tischfield Jay, Duan Jubao, Edenberg Howard J, Kreimer Anat, Hart Ronald P, Pang Zhiping P

Abstract excerpt

Polygenic risk scores (PRSs) assess genetic susceptibility to alcohol use disorder (AUD), yet their molecular implications remain underexplored. Neuroimmune interactions, particularly in microglia, are recognized as notable contributors to AUD pathophysiology. We investigated the interplay between AUD PRS and ethanol in human microglia derived from iPSCs from individuals with AUD high-PRS (diagnosed with AUD) or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Synapses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alcoholism

Share to Coculture Techniques

Share to Ethanol

Share to Induced Pluripotent Stem Cells

Share to Microglia

Share to Multifactorial Inheritance

Share to Phagocytosis

Source

Open in PubMed Open full text

Identifiers

PMID: 39514655
DOI: 10.1126/sciadv.ado5820
PMCID: PMC11546823

Genes

CD68
CLEC7A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model.PMID 39514655Read ↗

Polygenic Risk for Alcohol Use Disorder Affects Cellular Responses to Ethanol Exposure in a Human Microglial Cell ModelSemantic proximity Read ↗

Ethanol induces neuroimmune dysregulation and soluble TREM2 generation in a human iPSC neuron, astrocyte, microglia triculture modelSemantic proximity Read ↗

Cortical reactive microglia activate astrocytes, increasing neurodegeneration in human alcohol use disorderSemantic proximity Read ↗

Deep Proteomic Profiling of Human Stem Cell-Derived Microglia: Insights Into Inflammatory and Alcohol-Induced ReactivitySemantic proximity Read ↗

Deep proteome profiling reveals novel pathways associated with pro-inflammatory and alcohol-induced microglial activation phenotypes.Semantic proximity Read ↗

Increased expression of M1 and M2 phenotypic markers in isolated microglia after four-day binge alcohol exposure in male rats.Semantic proximity Read ↗

Phenotypic and Functional Alterations in Peripheral Blood Mononuclear Cell-Derived Microglia in a Primate Model of Chronic Alcohol ConsumptionSemantic proximity Read ↗

Integrated Single-Cell Multiomic Profiling of Caudate Nucleus Suggests Key Mechanisms in Alcohol Use DisorderSemantic proximity Read ↗

Alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behaviorSemantic proximity Read ↗

Chronic ethanol drinking in non-human primates induces inflammatory cathepsin gene expression in alveolar macrophages accompanied by functional defectsSemantic proximity Read ↗

Alcohol-responsive genes identified in human iPSC-derived neural culturesSemantic proximity Read ↗

Bulk and Single-cell Transcriptomic Brain Data Identify Overlapping Processes and Cell-types with Human AUD and Mammalian Models of Alcohol UseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.