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Article

Deep proteome profiling reveals novel pathways associated with pro-inflammatory and alcohol-induced microglial activation phenotypes.

Journal of proteomics - 30 May 2020

Guergues Jennifer, Wohlfahrt Jessica, Zhang Ping, Liu Bin, Stevens Stanley M

Abstract excerpt

Microglia, the resident immune cells of the brain, can exhibit a broad range of activation phenotypes, many of which have been implicated in several diseases and disorders of the central nervous system including those related to alcohol abuse. Given the complexity of global-scale molecular changes that define microglial activation, accurate phenotypic classification in the context of alcohol exposure is still...

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PMID: 32200115
DOI: 10.1016/j.jprot.2020.103753
PMCID: PMC7334825

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