Article

Chronic ethanol drinking in non-human primates induces inflammatory cathepsin gene expression in alveolar macrophages accompanied by functional defects

2021-07-31

Abstract excerpt

<h4>ABSTRACT</h4> Chronic alcohol drinking is associated with increased susceptibility to viral and bacterial respiratory pathogens. Investigating the effects of alcohol on the lung is challenging in humans because of the complexity of human drinking behavior and the challenge of obtaining samples. In this study, we utilize a rhesus macaque model of voluntary ethanol self-administration to study the effects of al...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 25af373d-46cd-54b9-998a-2620a4d7ad87
DOI: 10.1101/2021.07.30.454528

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chronic ethanol drinking in non-human primates induces inflammatory cathepsin gene expression in alveolar macrophages accompanied by functional defectsDOI 10.1101/2021.07.30.454528Read

Transcriptional, epigenetic, and functional reprogramming of blood monocytes in non-human primates following chronic alcohol drinkingSemantic proximity Read

Transcriptional and Epigenetic Regulation of Monocyte and Macrophage Dysfunction by Chronic Alcohol ConsumptionSemantic proximity Read

Chronic alcohol consumption dysregulates innate immune response to SARS-CoV-2 in the lungSemantic proximity Read

Transcriptome Profiling Reveals Disruption of Innate Immunity in Chronic Heavy Ethanol Consuming Female Rhesus MacaquesSemantic proximity Read

Alcohol Consumption Modulates Host Defense in Rhesus Macaques by Altering Gene Expression in Circulating LeukocytesSemantic proximity Read

Dose-dependent effects of chronic alcohol drinking on peripheral immune responsesSemantic proximity Read

Restricted immunological and cellular pathways are shared by murine models of chronic alcohol consumptionSemantic proximity Read

Epigenetics of alcohol-related liver diseasesSemantic proximity Read

Polygenic Risk for Alcohol Use Disorder Affects Cellular Responses to Ethanol Exposure in a Human Microglial Cell ModelSemantic proximity Read

Deep proteome profiling reveals novel pathways associated with pro-inflammatory and alcohol-induced microglial activation phenotypes.Semantic proximity Read

Ambiguous Pathogenic Roles of Macrophages in Alcohol-Associated Liver DiseasesSemantic proximity Read

Macrophages and Alcohol-Related Liver Inflammation.Semantic proximity Read