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Article

Cortical reactive microglia activate astrocytes, increasing neurodegeneration in human alcohol use disorder

2025-04-29

Abstract excerpt

Reactive microglia are associated with multiple brain diseases that may have specific disease phenotypes. Studies of human cortical microglia in alcohol use disorder (AUD) have characterized reactive microglial subtypes by transcriptome or histology. Preclinical studies have found proinflammatory signaling and microglia contribute to increases in alcohol drinking and preference, behaviors unique to AUD. This study...

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Identifiers and source

Literature Corpus work
e07fc3f2-64bc-55c3-802a-be74354c55f2
DOI
10.1101/2025.04.25.650687
Open publication

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Cortical reactive microglia activate astrocytes, increasing neurodegeneration in human alcohol use disorderDOI 10.1101/2025.04.25.650687
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