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Article

A new cancer progression model: From synthetic tumors to real data and back.

PLoS computational biology - 1 Jun 2026

Volpatto Daniela, Contaldo Sandro Gepiro, Pernice Simone, Beccuti Marco, Cordero Francesca, Sirovich Roberta

Abstract excerpt

Intratumor heterogeneity (ITH) arises from the combined effects of genetic alterations, clonal interactions, and environmental constraints, and plays a central role in therapeutic resistance and disease progression. While ITH has been extensively documented in empirical tumor data, the scientific debate regarding the biological mechanisms underlying this heterogeneity remains complex, highlighting the need for...

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PMID: 42341031
DOI: 10.1371/journal.pcbi.1013991
PMCID: PMC13327523

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