Article

Type I interferons sensitise HIV-1-reactivating T-cells for NK cell-mediated elimination despite HDACi-imposed dysregulation of innate immunity

2020-05-05

Abstract excerpt

<h4>ABSTRACT</h4> Shock-and-kill is one of the most advanced, yet unrealized, concepts towards establishment of HIV-1 cure. Treatment with latency-reversing agents (LRAs), including histone deacetylase inhibitors (HDACis) exerting chromatin remodelling and gene expression reprogramming, combined with anti-retroviral therapy reactivates HIV-1 transcription in vitro , ex vivo and in vivo . However, HDACi treatme...

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Literature Corpus work: 65c430df-36f2-503f-a0ce-b915175f45de
DOI: 10.1101/2020.05.04.075119

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