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Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies

1 Dec 2009

Abstract excerpt

The persistence of HIV-1 latent reservoirs represents a major barrier to virus eradication in infected patients under HAART since interruption of the treatment inevitably leads to a rebound of plasma viremia. Latency establishes early after infection notably (but not only) in resting memory CD4+ T cells and involves numerous host and viral trans-acting proteins, as well as processes such as transcriptional...

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PMID: 19961595
DOI: 10.1186/1742-4690-6-111

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