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The Current Status of Latency Reversing Agents for HIV-1 Remission

29 Sept 2021

Abstract excerpt

Combinatory antiretroviral therapy (cART) reduces human immunodeficiency virus type 1 (HIV-1) replication but is not curative because cART interruption almost invariably leads to a rapid rebound of viremia due to the persistence of stable HIV-1-infected cellular reservoirs. These reservoirs are mainly composed of CD4+T cells harboring replication-competent latent proviruses. A broadly explored approach to reduce...

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PMID: 34586875
DOI: 10.1146/annurev-virology-091919-103029

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