Article

Histone deacetylase inhibitors butyrate and bufexamac inhibit <i>de novo</i> HIV-1 infection in CD4 T-cells

2020-05-01

Abstract excerpt

While current combined antiretroviral therapy (cART) allows control of HIV replication in patients and effectively suppresses plasma viral loads, it is unable to target latent reservoirs, which are responsible for virus rebound after discontinuation of therapy. Several histone deacetylase inhibitors (HDACIs) have been shown to target reservoirs and to reactivate latent HIV. While this effect is highly desired, it...

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Literature Corpus work: 006fcae1-7e75-5115-847c-f858e65b3da3
DOI: 10.1101/2020.04.29.067884

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