Inhibition of ALKBH5 demethylase of m6A pathway potentiates HIV-1 reactivation from latency

Abstract excerpt

Current latency-reversing agents (LRAs) employed in the “shock-and-kill” strategy primarily focus on relieving epigenetic and transcriptional blocks to reactivate the latent HIV-1. However, their clinical efficacy is limited, partly due to their inability to fully reverse latency and the lack of LRAs specifically targeting post-transcriptional mechanisms. N6-methyladenosine (m 6 A) modification in HIV-1 RNA is...

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