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Therapy for Latent HIV-1 Infection: The Role of Histone Deacetylase Inhibitors

13 Feb 2013

Abstract excerpt

Persistence of HIV-1 in latently infected CD4(+) T-cells prevents eradication in HIV-infected treated patients. Latency is characterized by a reversible silencing of transcription of integrated HIV-1. Several molecular mechanisms have been described which contribute to latency, including the establishment and maintenance of repressive chromatin on the HIV-1 promoter. Histone deacetylation is a landmark...

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PMID: 24318952
DOI: 10.3851/imp2551

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