Article
Systematic dissection of phenotypic, functional, and tumorigenic heterogeneity of human prostate cancer cells.
Oncotarget - 15 Sept 2015
Liu Xin, Chen Xin, Rycaj Kiera, Chao Hsueh-Ping, Deng Qu, Jeter Collene, Liu Can, Honorio Sofia, Li Hangwen, Davis Tammy, Suraneni Mahipal, Laffin Brian, Qin Jichao, Li Qiuhui, Yang Tao, Whitney Pamela, Shen Jianjun, Huang Jiaoti, Tang Dean G
Abstract excerpt
Human cancers are heterogeneous containing stem-like cancer cells operationally defined as cancer stem cells (CSCs) that possess great tumor-initiating and long-term tumor-propagating properties. In this study, we systematically dissect the phenotypic, functional and tumorigenic heterogeneity in human prostate cancer (PCa) using xenograft models and >70 patient tumor samples. In the first part, we further...
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