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Article

PI3K/AKT pathway activation in acute myeloid leukaemias is not associated with AKT1 pleckstrin homology domain mutation.

British journal of haematology - 1 Feb 2008

Tibes Raoul, Kornblau Steven M, Qiu Yihua, Mousses Spyro M, Robbins Christiane, Moses Tracy, Carpten John D

Abstract excerpt

Despite its' central role, the precise mechanisms of the phosphoinositide 3-kinase/Akt (PI3K)/Akt pathway activation in acute myeloid leukaemia (AML) have not been elucidated. Recently, a recurrent novel AKT1 pleckstrin homology domain (PHD) mutation leading to membrane translocation, constitutive AKT activation and leukaemia development in mice was described. To assess AKT1 PHD mutations in AML, we sequenced 57...

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Topics

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Share to Blood Proteins
Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphatidylinositol 3-Kinases

Share to Phosphoproteins

Share to Protein Array Analysis

Share to Proto-Oncogene Proteins c-akt

Share to src Homology Domains

Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 18053070
DOI: 10.1111/j.1365-2141.2007.06920.x
PMCID: PMC3385948

Genes

AKT1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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