Article
Two acute myeloid leukemia patient subsets are identified based on the constitutive PI3K-Akt-mTOR signaling of their leukemic cells; a functional, proteomic, and transcriptomic comparison.
Expert opinion on therapeutic targets - 1 Jul 2018
Nepstad Ina, Hatfield Kimberley J, Aasebø Elise, Hernandez-Valladares Maria, Brenner Annette K, Bartaula-Brevik Sushma, Berven Frode, Selheim Frode, Skavland Jørn, Gjertsen Bjørn Tore, Reikvam Håkon, Bruserud Øystein
Abstract excerpt
OBJECTIVES: Constitutive signaling through the phosphatidylinositol-3-kinase-Akt-mammalian target of rapamycin (PI3K-Akt-mTOR) pathway is present in acute myeloid leukemia (AML) cells. The aim of the study was to compare constitutive PI3K-Akt-mTOR activation of primary AML cells for a large group of unselected patients. METHODS: We investigated expression and phosphorylation of 18 mediators in the PI3K-Akt-mTOR...
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