Article

A phylogenetic codon substitution model for antibody lineages

2016-09-28

Abstract excerpt

Phylogenetic methods have shown promise in understanding the development of broadly neutralizing antibody lineages (bNAbs). However, the mutational process that generates these lineages – somatic hypermutation (SHM) – is biased by hotspot motifs, which violates important assumptions in most phylogenetic substitution models. Here, we develop a modified GY94-type substitution model that partially accounts for this c...

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Literature Corpus work: 65463aff-04df-5910-9bc6-fed9c5d8c62c
DOI: 10.1101/078279

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