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Article

A Phylogenetic Codon Substitution Model for Antibody Lineages.

Genetics - 1 May 2017

Hoehn Kenneth B, Lunter Gerton, Pybus Oliver G

Abstract excerpt

Phylogenetic methods have shown promise in understanding the development of broadly neutralizing antibody lineages (bNAbs). However, the mutational process that generates these lineages, somatic hypermutation, is biased by hotspot motifs which violates important assumptions in most phylogenetic substitution models. Here, we develop a modified GY94-type substitution model that partially accounts for this context...

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Identifiers

PMID: 28315836
DOI: 10.1534/genetics.116.196303
PMCID: PMC5419485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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