Back to search

Article

Phylogenetic analysis of migration, differentiation, and class switching in B cells

2020-05-31

Abstract excerpt

B cells undergo rapid mutation and selection for antibody binding affinity when producing antibodies capable of neutralizing pathogens. This evolutionary process can be intermixed with migration between tissues, differentiation between cellular subsets, and switching between functional isotypes. B cell receptor (BCR) sequence data has the potential to elucidate important information about these processes. However,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b6cc3c6c-3254-51b4-9cad-27048ae548e5
DOI
10.1101/2020.05.30.124446
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Phylogenetic analysis of migration, differentiation, and class switching in B cellsDOI 10.1101/2020.05.30.124446
TRIBAL: Tree Inference of B cell Clonal LineagesSemantic proximity
Repertoire-wide phylogenetic models of B cell molecular evolution reveal evolutionary signatures of aging and vaccinationSemantic proximity
Repertoire-wide phylogenetic models of B cell molecular evolution reveal evolutionary signatures of aging and vaccinationSemantic proximity
Quantifying selection in high-throughput Immunoglobulin sequencing data setsSemantic proximity
Convergent Sequence Features of Antiviral B CellsSemantic proximity
The Diversity and Molecular Evolution of B-Cell Receptors during Infection.Semantic proximity
Inferring B cell phylogenies from paired heavy and light chain BCR sequences with DowserSemantic proximity
Signatures of selection in the human antibody repertoire: Selective sweeps, competing subclones, and neutral driftSemantic proximity
Reconstructing the evolutionary history of a B cell lineage with minimum spanning tree and genotype abundancesSemantic proximity
Reconstructing the evolutionary history of a B cell lineage with minimum spanning tree and genotype abundancesSemantic proximity
Signatures of Selection in the Human Antibody Repertoire: Selective Sweeps, Competing Subclones, and Neutral DriftSemantic proximity
The evolution within usSemantic proximity
Select a neighboring publication to make it the new centre.