Article

Modelling the Decay of Hotspot Motifs in Broadly Neutralizing Antibody Lineages

2016-05-26

Abstract excerpt

Phylogenetic methods have shown great promise in understanding the development of broadly neutralizing antibody lineages (bNAbs). However, mutational process for generating these lineages - somatic hypermutation (SHM) - is biased by hotspot motifs, which violates important assumptions in most phylogenetic substitution models. Here, we develop a modified GY94-type substitution model which partially accounts for thi...

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Literature Corpus work: 1df7109a-db3a-5f23-a129-57458d9deb96
DOI: 10.1101/055517

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