Article

Development of antibody-dependent cell cytotoxicity function in HIV-1 antibodies

2020-09-25

Abstract excerpt

A prerequisite for the design of an HIV vaccine that elicits protective antibodies is understanding the developmental pathways that result in desirable antibody features. The development of antibodies that mediate antibody-dependent cellular cytotoxicity (ADCC) is particularly relevant because such antibodies have been associated with HIV protection in humans. We reconstructed the developmental pathways of six hum...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 65267505-e08f-5132-bffb-e0609b188311
DOI: 10.1101/2020.09.24.312066

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Development of antibody-dependent cell cytotoxicity function in HIV-1 antibodiesDOI 10.1101/2020.09.24.312066Read

Epitope Specificity of Human Immunodeficiency Virus-1 Antibody Dependent Cellular Cytotoxicity [ADCC] ResponsesSemantic proximity Read

Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutationsSemantic proximity Read

Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations.Semantic proximity Read

Mathematical Modelling Indicates Th-cell Targeted Antibody-Dependent Cellular Cytotoxic Is a Crucial Obstacle Hurdling HIV Vaccine DevelopmentSemantic proximity Read

Antibody-virus co-evolution in HIV infection: paths for HIV vaccine development.Semantic proximity Read

Functional Improbable Antibody Mutations Critical for HIV Broadly Neutralizing Antibody DevelopmentSemantic proximity Read

Mining HIV controllers for broad and functional antibodies to recognize and eliminate HIV-infected cellsSemantic proximity Read

B cell receptor analysis using single cell sequencing reveals preferential antibody expression in a HIV candidate vaccine studySemantic proximity Read

Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing.Semantic proximity Read

Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors.Semantic proximity Read

The unmutated common ancestor of Gp41 conformational epitope targeting variable heavy chain 1-02 utilizing antibodies maintains antibody dependent cell cytotoxicitySemantic proximity Read

Lack of ADCC Breadth of Human Nonneutralizing Anti-HIV-1 AntibodiesSemantic proximity Read