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Article

Mining HIV controllers for broad and functional antibodies to recognize and eliminate HIV-infected cells

1 May 2021

Abstract excerpt

HIV monoclonal antibodies for viral reservoir eradication strategies will likely need to recognize reactivated infected cells and potently drive Fc-mediated innate effector cell activity. We systematically characterize a library of 185 HIV-envelope-specific antibodies derived from 15 spontaneous HIV controllers (HCs) that selectively exhibit robust serum Fc functionality and compared them to broadly neutralizing...

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Identifiers

PMID: 34038720
DOI: 10.1016/j.celrep.2021.109167

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