Article
Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing.
Science (New York, N.Y.) - 16 Sept 2011
Wu Xueling, Zhou Tongqing, Zhu Jiang, Zhang Baoshan, Georgiev Ivelin, Wang Charlene, Chen Xuejun, Longo Nancy S, Louder Mark, McKee Krisha, O'Dell Sijy, Perfetto Stephen, Schmidt Stephen D, Shi Wei, Wu Lan, Yang Yongping, Yang Zhi-Yong, Yang Zhongjia, Zhang Zhenhai, Bonsignori Mattia, Crump John A, Kapiga Saidi H, Sam Noel E, Haynes Barton F, Simek Melissa, Burton Dennis R, Koff Wayne C, Doria-Rose Nicole A, Connors Mark, Mullikin James C, Nabel Gary J, Roederer Mario, Shapiro Lawrence, Kwong Peter D, Mascola John R
Abstract excerpt
Antibody VRC01 is a human immunoglobulin that neutralizes about 90% of HIV-1 isolates. To understand how such broadly neutralizing antibodies develop, we used x-ray crystallography and 454 pyrosequencing to characterize additional VRC01-like antibodies from HIV-1-infected individuals. Crystal structures revealed a convergent mode of binding for diverse antibodies to the same CD4-binding-site epitope. A functional...
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