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Article

Lack of ADCC Breadth of Human Nonneutralizing Anti-HIV-1 Antibodies

26 Jan 2017

Abstract excerpt

ABSTRACT Anti-human immunodeficiency virus type 1 (HIV-1) nonneutralizing antibodies (nnAbs) capable of antibody-dependent cellular cytotoxicity (ADCC) have been identified as a protective immune correlate in the RV144 vaccine efficacy trial. Broadly neutralizing antibodies (bNAbs) also mediate ADCC in cell culture and rely on their Fc region for optimal efficacy in animal models. Here, we selected 9 monoclonal...

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PMID: 28122982
DOI: 10.1128/jvi.02440-16

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