Article
Visualizing and exploring patterns of large mutational events with SigProfilerMatrixGenerator.
BMC genomics - 21 Aug 2023
Khandekar Azhar, Vangara Raviteja, Barnes Mark, Díaz-Gay Marcos, Abbasi Ammal, Bergstrom Erik N, Steele Christopher D, Pillay Nischalan, Alexandrov Ludmil B
Abstract excerpt
BACKGROUND: All cancers harbor somatic mutations in their genomes. In principle, mutations affecting between one and fifty base pairs are generally classified as small mutational events. Conversely, large mutational events affect more than fifty base pairs, and, in most cases, they encompass copy-number and structural variants affecting many thousands of base pairs. Prior studies have demonstrated that examining...
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