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Article

MesKit: a tool kit for dissecting cancer evolution of multi-region tumor biopsies through somatic alterations.

GigaScience - 21 May 2021

Liu Mengni, Chen Jianyu, Wang Xin, Wang Chengwei, Zhang Xiaolong, Xie Yubin, Zuo Zhixiang, Ren Jian, Zhao Qi

Abstract excerpt

BACKGROUND: Multi-region sequencing (MRS) has been widely used to analyze intra-tumor heterogeneity (ITH) and cancer evolution. However, comprehensive analysis of mutational data from MRS is still challenging, necessitating complicated integration of a plethora of computational and statistical approaches. FINDINGS: Here, we present MesKit, an R/Bioconductor package that can assist in characterizing genetic ITH...

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Identifiers

PMID: 34018555
DOI: 10.1093/gigascience/giab036
PMCID: PMC8138830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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