Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic lineage tracing defines myofibroblast origin and function in the injured heart

22 Jul 2016

Abstract excerpt

Cardiac fibroblasts convert to myofibroblasts with injury to mediate healing after acute myocardial infarction (MI) and to mediate long-standing fibrosis with chronic disease. Myofibroblasts remain a poorly defined cell type in terms of their origins and functional effects in vivo. Here we generate Postn (periostin) gene-targeted mice containing a tamoxifen-inducible Cre for cellular lineage-tracing analysis....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Fibrosis and Remodeling
Share to Cardiac Structural Anomalies and Repair
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27447449
DOI: 10.1038/ncomms12260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic lineage tracing defines myofibroblast origin and function in the injured heartPMID 27447449Read ↗

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heartSemantic proximity Read ↗

tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regenerationSemantic proximity Read ↗

A novel transgenic Cre allele to label mouse cardiac conduction system.Semantic proximity Read ↗

The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors.Semantic proximity Read ↗

Cellular drivers of injury response and regeneration in the adult zebrafish heartSemantic proximity Read ↗

ptx3a+ fibroblast/epicardial cells provide a transient macrophage niche to promote heart regenerationSemantic proximity Read ↗

Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart FailureSemantic proximity Read ↗

Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling.Semantic proximity Read ↗

Adventitial leptin receptor-expressing fibroblasts are preferential contributors to fibrotic remodeling of the heart post infarctionSemantic proximity Read ↗

Transcriptional Control of Cell Lineage Development in Epicardium-Derived CellsSemantic proximity Read ↗

Spatio-temporal dynamics of the fibrotic niche in cardiac repairSemantic proximity Read ↗

Cre-loxP-mediated genetic lineage tracing: Unraveling cell fate and origin in the developing heartSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.