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Article

Periostin contributes to differential sex-linked gene expression during infarct healing.

American journal of physiology. Heart and circulatory physiology - 1 Apr 2026

Abual'anaz Besher M, Cayer Lucien G J, Haji Rasul Sara S, Rattan Sunil G, Lambos Jonathon C, Evans Taylor I M, Rabinovich-Nikitin Inna, Kirshenbaum Lorrie A, Kienesberger Petra C, Wigle Jeffrey T, Czubryt Michael P, Dixon Ian M C

Abstract excerpt

Periostin (Postn) is a matricellular protein that plays a crucial role in cardiac fibrosis following myocardial infarction (MI). However, the role of Postn in infarct healing to date has been derived from experiments conducted exclusively on male animals, leaving its sex-specific functions unaddressed. Thus, we investigated the sex-specific role of Postn in acute wound healing and extracellular matrix (ECM)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41696761
DOI: 10.1152/ajpheart.00675.2025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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