Article

Transcriptional deconvolution reveals consistent functional subtypes of pancreatic cancer epithelium and stroma

2018-03-26

Abstract excerpt

<h4>Summary</h4> Bulk tumor tissues comprise intermixed populations of neoplastic cells and multiple lineages of stromal cells. We used laser capture microdissection and RNA sequencing to disentangle the transcriptional programs active in the malignant epithelium and stroma of pancreatic ductal adenocarcinoma (PDA). This led to the development of a new algorithm (ADVOCATE) that accurately predicts the compartment...

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Literature Corpus work: 64b9bff2-3e33-58ff-a73a-62e2f7c5fe41
DOI: 10.1101/288779

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