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Microdissected pancreatic cancer proteomes reveal tumor heterogeneity and therapeutic targets

7 Jul 2020

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a relative paucity of cancer cells that are surrounded by an abundance of nontumor cells and extracellular matrix, known as stroma. The interaction between stroma and cancer cells contributes to poor outcome, but how proteins from these individual compartments drive aggressive tumor behavior is not known. Here, we report the proteomic analysis of...

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PMID: 32634123
DOI: 10.1172/jci.insight.138290

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