Article

SARS-CoV-2 NSP12 utilizes various host splicing factors for replication and splicing regulation

2023-04-27

Abstract excerpt

<h4>Background: </h4> The RNA-dependent RNA polymerase (RdRp) is a crucial element in the replication and transcription of RNA viruses. Although the RdRps of lethal human coronaviruses SARS-CoV-2, SARS-CoV, and MARS-CoV have been extensively studied, the molecular mechanism of the catalytic subunit NSP12, which is involved in pathogenesis, remains unclear. <h4>Results: </h4> In this study, the biochemical and cel...

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Literature Corpus work: 649c1977-4a53-553e-bdf2-3e95e744b7f7
DOI: 10.21203/rs.3.rs-2853386/v1

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