Article

Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infection

2020-12-22

Abstract excerpt

<h4>Summary</h4> SARS-CoV-2 uses subgenomic (sg)RNA to produce viral proteins for replication and immune evasion. We applied long-read RNA and cDNA sequencing to in vitro human and primate infection models to study transcriptional dynamics. Transcription-regulating sequence (TRS)-dependent sgRNA was upregulated earlier in infection than TRS-independent sgRNA. An abundant class of TRS-independent sgRNA consisting...

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Literature Corpus work: 5ddaa650-6b08-50fd-8106-23d784c95742
DOI: 10.1101/2020.12.22.423893

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