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The Role of Coronavirus RNA-Processing Enzymes in Innate Immune Evasion

17 Jun 2021

Abstract excerpt

Viral RNA sensing triggers innate antiviral responses in humans by stimulating signaling pathways that include crucial antiviral genes such as interferon. RNA viruses have evolved strategies to inhibit or escape these mechanisms. Coronaviruses use multiple enzymes to synthesize, modify, and process their genomic RNA and sub-genomic RNAs. These include Nsp15 and Nsp16, whose respective roles in RNA capping and...

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PMID: 34204549
DOI: 10.3390/life11060571

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