Article

Soluble Immune Factor Profiles in Blood and CSF Associated with LRRK2 Mutations and Parkinson’s Disease

2025-03-24

Abstract excerpt

<h4>Background and Objectives</h4> Mutations in the Leucine-rich repeat kinase 2 ( LRRK2 ) gene are one of the most common genetic causes of Parkinson’s disease (PD) and are linked to immune dysregulation in both the central nervous system and periphery. However, peripheral and central profiles of soluble immune factors associated with LRRK2 mutations and PD have not been comprehensively characterized. Using se...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6487819e-0fb6-5316-8815-728637939493
DOI: 10.1101/2025.03.20.644460

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Soluble Immune Factor Profiles in Blood and CSF Associated with LRRK2 Mutations and Parkinson’s DiseaseDOI 10.1101/2025.03.20.644460Read

Integrated Biofluid Proteomics Identified Dynamic Functional Biomarkers of <i>LRRK2</i> -Linked Parkinson’s Disease ProgressionSemantic proximity Read

LRRK2 as a target for modulating immune system responses.Semantic proximity Read

Single molecule array measures of LRRK2 kinase activity in serum link Parkinson’s disease severity to peripheral inflammationSemantic proximity Read

Proteome Wide Association Studies of LRRK2 variants identify novel causal and druggable for Parkinson’s diseaseSemantic proximity Read

Increased peripheral inflammation in asymptomatic leucine‐rich repeat kinase 2 mutation carriersSemantic proximity Read

Contrasting patterns of interleukin signalling in LRRK2 and idiopathic Parkinson’sSemantic proximity Read

Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s diseaseSemantic proximity Read

Gut-related Immune Activation in Parkinson’s Disease with Asian <i>LRRK2</i> Risk Variants: Associations with Systemic Inflammation and Clinical SeveritySemantic proximity Read

Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2.Semantic proximity Read

Proteome profiling of cerebrospinal fluid reveals biomarker candidates for Parkinson’s diseaseSemantic proximity Read

LRRK2 and the Immune System.Semantic proximity Read

Transcriptional profile of Parkinson blood mononuclear cells with LRRK2 mutation.Semantic proximity Read