Article

Gut-related Immune Activation in Parkinson’s Disease with Asian <i>LRRK2</i> Risk Variants: Associations with Systemic Inflammation and Clinical Severity

2026-07-14

Abstract excerpt

<h4>ABSTRACT</h4> LRRK2 is implicated in Parkinson’s disease (PD) microbiome–gut–brain axis. We compared plasma lipopolysaccharide-binding protein (LBP) and soluble CD14 (sCD14), markers of gut permeability and endotoxin exposure, in PD patients with/without LRRK2 p.G2385R and/or p.R1628P, and controls, and examined their associations with systemic inflammation and clinical severity. Neither marker differed betw...

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Literature Corpus work: effbbc74-fac9-5a5a-9a16-5e95c31caedf
DOI: 10.64898/2026.07.10.26357757

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