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Proteome profiling of cerebrospinal fluid reveals biomarker candidates for Parkinson’s disease

1 Jun 2022

Abstract excerpt

Parkinson's disease (PD) is a growing burden worldwide, and there is no reliable biomarker used in clinical routines to date. Cerebrospinal fluid (CSF) is routinely collected in patients with neurological symptoms and should closely reflect alterations in PD patients' brains. Here, we describe a scalable and sensitive mass spectrometry (MS)-based proteomics workflow for CSF proteome profiling. From two...

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PMID: 35732154
DOI: 10.1016/j.xcrm.2022.100661

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