Article

Hypomethylation of miR-17-92 cluster in lupus T cells and no significant role for genetic factors in the lupus-associated DNA methylation signature

2022-02-22

Abstract excerpt

<h4>Objectives</h4> Epigenetic dysregulation plays an important role in the pathogenesis of lupus, a systemic autoimmune disease characterized by autoantibody production. Lupus T cells demonstrate aberrant DNA methylation patterns dominated by hypomethylation of interferon-regulated genes. The objective of this study was to identify additional disease-associated DNA methylation changes in naïve CD4+ T cells from a...

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Literature Corpus work: 64833452-b807-5f49-902f-cebc3f1d519c
DOI: 10.1101/2022.02.21.22271293

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