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Article

The role of epigenetic variation in the pathogenesis of systemic lupus erythematosus.

Arthritis research & therapy - 1 Jan 2011

Hughes Travis, Sawalha Amr H

Abstract excerpt

The focus of the present review is on the extent to which epigenetic alterations influence the development of systemic lupus erythematosus. Lupus is a systemic autoimmune disease characterized by the production of autoantibodies directed at nuclear self-antigens. A DNA methylation defect in CD4+ T cells has long been observed in idiopathic and drug-induced lupus. Recent studies utilizing high-throughput...

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Share to CD4-Positive T-Lymphocytes
Share to Epigenesis, Genetic
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune Cell Function and Interaction

Share to Lupus Erythematosus, Systemic

Share to Systemic Lupus Erythematosus Research

Share to T-cell and B-cell Immunology

Source

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Identifiers

PMID: 22044622
DOI: 10.1186/ar3484
PMCID: PMC3308098

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