Article

Hypomethylation of <i>STAT1</i> and <i>HLA-DRB1</i> is associated with type-I interferon-dependent <i>HLA-DRB1</i> expression in lupus CD8+ T cells

2018-08-22

Abstract excerpt

<h4>Objective</h4> We examined genome-wide DNA methylation changes in CD8+ T cells from lupus patients and controls, and investigated the functional relevance of some of these changes in lupus. <h4>Methods</h4> Genome-wide DNA methylation of lupus and age, sex, and ethnicity-matched control CD8+ T cells was measured using the Infinium MethylationEPIC arrays. Measurement of relevant cell subsets was performed via...

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Literature Corpus work: 99108c9c-d48d-5d70-a99b-afb7cc62c21d
DOI: 10.1101/398081

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