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Article

Ethnicity-specific epigenetic variation in naïve CD4+ T cells and the susceptibility to autoimmunity

24 Nov 2015

Abstract excerpt

BACKGROUND: Genetic and epigenetic variability contributes to the susceptibility and pathogenesis of autoimmune diseases. T cells play an important role in several autoimmune conditions, including lupus, which is more common and more severe in people of African descent. To investigate inherent epigenetic differences in T cells between ethnicities, we characterized genome-wide DNA methylation patterns in naïve...

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PMID: 26609326
DOI: 10.1186/s13072-015-0037-1

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