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Article

DNA methylation patterns and disease activity in a longitudinal cohort of lupus patients

2020-09-22

Abstract excerpt

Epigenetic dysregulation is implicated in the pathogenesis of lupus. We performed a longitudinal analysis to assess changes in DNA methylation in lupus granulocytes over 4 years of follow up and across disease activity levels using 229 patient samples. We demonstrate that DNA methylation profiles in lupus are influenced by ancestry-specific genetic variants and are highly stable over time. DNA methylation levels i...

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Literature Corpus work
605b2915-fdbc-5be3-b44b-9dbde56336ce
DOI
10.1101/2020.09.18.20197525
Open publication

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DNA methylation patterns and disease activity in a longitudinal cohort of lupus patientsDOI 10.1101/2020.09.18.20197525
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